Repurposing is an efficient approach to drug development
Repurposing is an efficient approach to drug development, as it makes use of existing knowledge on pharmaceuticals and their mechanism(s) of action, thus minimizing the need for much of the preclinical and early safety work required by new chemical entity (NCE) drug discovery and development.
Many bioinformaticians believe that drug repurposing is one potential solution to Eroom’s Law: the observation that the efficiency of drug development halves about every decade.2 Thus, repurposing may offer a systematic approach to increasing the pace of therapeutic development. One of the benefits of drug repurposing is cost reduction; recent estimates suggest that marketing approval through repurposing can cost ∼70% less than that for NCE drug development projects. Drug repurposing is often much faster than NCE drug development: although the time from discovery to regulatory approval of an NCE may require 12 years or longer, repurposing can establish the same task in <6 years, nearly half the conventional time.3
Data driven and genomics guided drug re-purposing makes it possible to find totally new mechanisms of action that may not have been previously suspect
A research study conducted by the Connectivity Map project from Broad Institute of Harvard & MIT based on the advances in genomics set up a systems - based approach to drug repurposing and discovery.
Instead of identifying the targets hit by a particular compound, say through a target-based screen, we can now measure and evaluate the genome-wide perturbation induced by a compound. In the case of the Connectivity Map, this perturbation was determined by transcriptional changes that result from exposing a cell line to a dose of the compound and measuring the changes in the transcriptome relative to untreated controls.
By measuring all genes at one time, we can obtain a system-wide snapshot of how exposure to a particular drug affects the entire cell line.
38% of Virginia's population has a Bachelor's degree.
The state has over 38% of it's adults with a bachelor degree or higher. Virginia has the nation’s fourth highest concentration of crucial science, technology, engineering and math (STEM) employees, making up 9% of the workforce in 2018. All of this in a right-to-work state with a minimal union presence — something companies prize.
Virginia has a significantly aging population with the median age of the state being 37.8 years
Average age of Amazon employees is 31 years. The median age of the state of Virginia is around 38 years. The rate of unemployment is 2%. This may seem like a deterrent in terms of job creation and also long term employment opportunities Amazon would offer to the people of Virginia.
Test Statement Description.
Chemoinformatics is an established discipline focusing on extracting, processing and extrapolating meaningful data from chemical structures.
Machine learning is currently one of the most important and rapidly evolving topics in computer-aided drug discovery
The world contains billions of people, to take whole-genome sequencing as the basis for medicine, billions of genomes will have to be sequenced. This is industrial scale and requires huge investments.
Obtaining genomic snapshots are not easy as DNA is very static and RNA is chemically unstable and degrades rapidly.
A picture of the genomic patterns in the tissues from affected and unaffected individuals can help obtain a molecular signature of a disease.
There are other factors beyond incentives that weighed-in in favor of North Virginia
Atleast according to Amazon's senior management following factors helped Virginia to win the deal.
Arguably, Virginia offered Amazon the best workforce
The deal offered to Amazon also included significant public investments in transportation and education which amounted to roughly $800 million along with the financial incentives offered.
Virginia offered to boost the local university curricula and to increase the tech workforce pipeline.
They already had one of the most educated workforces.
Choosing Virginia over New York City was the right business decision for Amazon
Virginia is listed at the top of the best states for business in 2019. The state offers the best workforce in the nation, according to a CNBC survey. The number of professionals in STEM careers is one of the highest in the region.
As part of the deal, Amazon was offered the following by the state of Virginia -
From Arlington County, it includes:
Choosing Virginia is a strategic decision made based on qualitative analysis, not quantitative.
On the corporate level, Amazon has faced and will face far more potential challenges emanating from the federal city in recent and coming years.
D.C.-centric issues include : -
Accordingly, the company has surged its lobbying in recent years, spending $13 million on lobbying in 2017, according to Amazon’s public financial disclosures. That’s more than quadruple the $2.5 million they spent as recently as 2012, according to the Center for Responsive Politics.
Virginia is not on the top 10 list of states that rank better for business growth, number of patent creation and taxation
Based on factors like business growth, patent creation and taxation following are the Top 10 States for Business to set up their HQs.
This is based on the report published by USNews.
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